Home /Archive /2015, Volume 11 /11(2) /Development and Testing of Complex Molecular Genetic Diagnosis of Genitourinary System Neoplasms

Development and Testing of Complex Molecular Genetic Diagnosis of Genitourinary System Neoplasms

TitleDevelopment and Testing of Complex Molecular Genetic Diagnosis of Genitourinary System Neoplasms
Publication TypeJournal Article
Year of Publication2015
AuthorsTelegeev, G, Polishchuk, L, Lisecka, T, Shvachko, L, Dybkov, M, Stakhovsky, O, Vitruk, І, Stakhovsky, E
Short TitleSci. innov.
DOI10.15407/scine11.02.035
Volume11
Issue2
SectionResearch and Engineering Innovative Projects of the National Academy of Sciences of Ukraine
Pagination35-43
LanguageEnglish
Abstract

A system for comprehensive non-invasive diagnostic of urogenital system neoplasms has been designed and tested on the basis of molecular genetic parameters (the tmprss2/erg rearrangement using reverse transcriptase polymerase chain reaction (PCR), the level of psa3/psa and cxcr4 gene expression using quantitative PCR, and the gstp1 gene promoter methylation status using methyl-specific PCR.
Keywordscxcr4 genes, diagnosis, erg, gstp1, malignant neoplasms of genitourinary system, psa, pсa3, tmprss2
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